Search Results for: profile

Mr. (Swipe) Right?

Longreads Pick

A profile of Tinder co-founder Sean Rad; the formerly ousted frontman is now back in charge of the company.

Published: Jan 11, 2016
Length: 23 minutes (5,873 words)

On the Brink of a Cure: An Innovative Immunologist’s Quest for an AIDS Vaccine

Louis Picker, an immunologist at Portland’s Oregon Health & Science University, believes he’s working toward a vaccine to prevent and cure AIDS: “I think within 15 years we’ll have both.” In 2013, his vaccine research showed the first evidence of monkeys eradicating the AIDS-causing virus from their bodies; he inoculated them with weakened CMV — or cytomegalovirus, an infectious agent in the herpes family — which not only pumped up their immune systems and fought off the virus, but killed it off entirely. At Portland Monthly, Jennifer Abbasi profiles the ambitious researcher, whose project’s first human study is set to begin later this year.

Picker set out to prevent AIDS, not cure it. In 2006, he and his team began vaccinating macaques against SIV, the monkey version of HIV. The researchers placed bits of SIV genes inside weakened CMV, hoping the macaques’ immune systems would then mount their natural immediate, large-scale response to CMV. “The immune system will make a response both to the CMV genes and to the SIV or HIV genes that will be in the same flavor, so to speak,” Picker explains. This approach contrasts sharply with that of most HIV vaccine projects, which typically focus on generating antibodies to block infection. Instead, Picker’s method aims to provoke T cells to prevent an infection from progressing to disease. Two years after he inoculated the first group of monkeys with the CMV-based vaccine, he exposed them to SIV.

In 2013, Nature reported Picker’s surprising findings: not only were most of the macaques able to control SIV, but over time their immune systems completely killed off the virus. It was the first evidence of monkeys eliminating the AIDS-causing virus from their bodies. Says Koff: “Louis straddles the prevention and the cure. The most intriguing thing about his vaccine is that the responding animals appear to clear the infection.”

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David Bowie, 1947-2016

Illustration by: Helen Green

The legendary musician died on Sunday of cancer. At the Awl, Alex Balk writes: “If you are under the age of 40 you live in a world he helped make, whether you’re aware of it or not. His importance transcends his work in a way that only a few other artists of his generation can claim.” Here are six stories about the rock star who left a mark on music, fashion, and art. Read more…

The Top 5 Longreads of the Week

New Haven. Photo: Wally Gobetz, Flickr

Below, our favorite stories of the week. Kindle users, you can also get them as a Readlist.
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Trivers’ Pursuit

Longreads Pick

A lively profile of Robert Trivers, a renegade scientist lauded as one of our greatest thinkers—despite a career peppered with mental breakdowns, public feuds, and near-death experiences.

Published: Jan 6, 2016
Length: 17 minutes (4,344 words)

How Homelessness Looks in the Tech Boom

It’s a familiar American tale: people living in poverty amid great wealth. In Palo Alto, California, where the per capita income is over twice the state average, the tech boom has driven real estate values up, and evictions have left many renters homeless. In the New Republic, Monica Potts profiles an elderly couple who lived in their van while searching for affordable housing, and portrays the hostilities and NIMBYism that Silicon Valley’s homeless face, as well as the social services available to them.

One night, about a month after leaving Cubberley, the police pulled Suzan and James over. Their registration was expired. “This officer, he got a wild hair, and he said, ‘I’m going to impound your car,’ and called the tow truck.” Suzan told me. They got out of the car. Without pushing and demanding, she realized, she was never going to get out of the situation. She told me she said to the officer, “This is our home, and if you impound it we will not have a home.” He insisted. “I said ‘That’s fine. You do that. We will stay right here. I will put the beds out, I will put what we need here, right here on the sidewalk.” Other officers arrived and talked to them. They asked Suzan whether, surely, there was some other place they could go. “I said, ‘We have no place to go, and we’re staying right here.’ I was going to make a stink. They were going to know about it.” Suzan told me people were poking their heads out of their homes, and she realized the bigger fuss she made, the more likely officers might decide just to leave them alone.

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Longreads Best of 2015: Under-Recognized Stories

We asked all of our contributors to Longreads Best of 2015 to tell us about a story they felt deserved more recognition in 2015. Here they are. Read more…

The Machiavelli of Maryland

Longreads Pick

A fascinating profile of Edward Luttwak—military strategist, classical scholar, cattle rancher, and an adviser to presidents, prime ministers, and the Dalai Lama.

Source: The Guardian
Published: Dec 9, 2015
Length: 28 minutes (7,000 words)

Longreads Best of 2015: Arts & Culture

We asked a few writers and editors to choose some of their favorite stories of the year in specific categories. Here, the best in arts and culture writing.

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Shannon Proudfoot
Senior writer with Sportsnet magazine

The Late, Great Stephen Colbert (Joel Lovell, GQ)

Stephen Colbert has pulled off the rare feat of being a public figure for the better part of a decade while keeping his true self almost entirely obscured behind a braying façade. Here, with such uncommon intelligence, sensitivity and nuance, Joel Lovell shows us who’s been under there the whole time. The writer is very present in the story, sifting through the meaning of what he finds and tugging us along behind him through reporting and writing that starts out rollicking and then turns surprisingly raw and emotional. But Lovell never gets in his own way or turns self-indulgent; that’s a tough thing to pull off. The word I kept coming back to in thinking about this story was “humane”—it just feels so complex and wise, and unexpectedly aching, buoyed with perfect, telling details and effortlessly excellent writing. Read more…

Longreads Best of 2015: Essays & Criticism

We asked a few writers and editors to choose some of their favorite stories of the year in specific categories. Here, the best in essays and criticism. Read more…