Search Results for: drugs

The Steroid Hunt

Longreads Pick

A brief history of how reporters first covered performance-enhancing drugs in Major League Baseball, starting with the time Baseball Weekly writer Pete Williams hit the gym with Ken Caminiti:

His post-workout high set him off to report on creatine, the supplement Baseball Weekly would dub the game’s “new gunpowder.”

Baseball Weekly had a decent travel budget and Williams was able to interview lots of players. The list now reads like a suspect list of the steroid era. Mark McGwire. Jason Giambi. Mike Piazza. They wanted to talk to Williams. The word cheater was barely in circulation. In the age when few ballplayers took weight lifting seriously, the players thought of themselves as innovators. Orioles center fielder Brady Anderson, whose home run total jumped from 16 in ’95 to 50 in ’96, pulled out supplement after supplement to show Williams. There’s this, Anderson said. And this … McGwire declared Power Creatine “the best product on the market today.”

Source: Grantland
Published: Jan 16, 2014
Length: 25 minutes (6,273 words)

How Scientists Are Using Fruit Flies to Find Alternative Cancer Treatments

“His name was Ross Cagan. He did not work for Schadt; he worked as a professor at Sinai. But they met every week, and after Schadt called on October 1 to tell Cagan about Stephanie Lee, he listened to Cagan’s idea for her. A month earlier, Cagan had started doing something that he said ‘had never been done before.’ He started creating ‘personalized flies’ for cancer patients. He took the mutations that scientists like Schadt had revealed and loaded them into flies, essentially giving the flies the same cancer that the patient had. Then he treated them. ‘Why a fly? You can do this in a fly. You can capture the complexities of the tumor.’

“A day after Cagan spoke with Schadt, Stephanie became the fifth person in the world to have a fly built in her image—or, rather, in the image of her cancer. In an ideal world, Cagan would have created as complex a creature as possible, burdening the fly with at least ten mutations. He gave Stephanie’s fly three, because ‘Stephanie is on the shorter course. We’re making the fly as complex as possible given her time.’ By October 11, however, Cagan already had ‘one possible drug suggestion for her’—or one possible combination of drugs, since he always tests at least two at a time. ‘In this center, the FDA will not allow us to put a novel drug in patient. To get a novel drug into a patient, we have to do a novel combination of [known] drugs. We have to use novel drug combinations that people have never seen before'”

– In Esquire, Mark Warren and Tom Junod tell the story of an Iraq War widow named Stephanie Lee who was diagnosed with terminal colon cancer, and how scientists at Mount Sinai are using her genetic data to find personalized treatments for her. Read more stories about fighting cancer.

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Photo: John Tann

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There’s a Whole New Way of Killing Cancer: Stephanie Lee Is the Test Case

Longreads Pick

Stephanie Lee, a 36-year-old Iraq War widow with two children is diagnosed with terminal colon cancer and told she has just a few years to live. A group of pioneering cancer specialists at the Icahn Institute at Mount Sinai use genetic data to figure out alternative treatments to “the standard of care” that could give her her life back:

His name was Ross Cagan. He did not work for Schadt; he worked as a professor at Sinai. But they met every week, and after Schadt called on October 1 to tell Cagan about Stephanie Lee, he listened to Cagan’s idea for her. A month earlier, Cagan had started doing something that he said “had never been done before.” He started creating “personalized flies” for cancer patients. He took the mutations that scientists like Schadt had revealed and loaded them into flies, essentially giving the flies the same cancer that the patient had. Then he treated them. “Why a fly? You can do this in a fly. You can capture the complexities of the tumor.”

A day after Cagan spoke with Schadt, Stephanie became the fifth person in the world to have a fly built in her image—or, rather, in the image of her cancer. In an ideal world, Cagan would have created as complex a creature as possible, burdening the fly with at least ten mutations. He gave Stephanie’s fly three, because “Stephanie is on the shorter course. We’re making the fly as complex as possible given her time.” By October 11, however, Cagan already had “one possible drug suggestion for her”—or one possible combination of drugs, since he always tests at least two at a time. “In this center, the FDA will not allow us to put a novel drug in patient. To get a novel drug into a patient, we have to do a novel combination of [known] drugs. We have to use novel drug combinations that people have never seen before.”

Source: Esquire
Published: Nov 20, 2013
Length: 60 minutes (15,090 words)

The Church That Doesn’t Believe in Seatbelts or Eyeglasses

“In the 20 years Nelson Clark has been First Century Gospel’s head pastor, the church’s message has also changed very little, especially in its core beliefs. Pastor Clark later sums these up in an email: how ‘the divine power of God … is able to heal our body without drugs or medicine; supply our needs without laid-up cash for the future; protect our family without firearms or anti-theft devices; bring about justice without legal action or attorneys; and to save our soul by a believing faith that endures to the end of our life.’

“As to what may seem idiosyncratic or even absurd, such as not wearing seatbelts or correcting bad eyesight with glasses, the explanations get interesting. The problem with seatbelts, Pastor Clark says, is that ‘anyplace we are told to do something in case something happens is a breach of faith or denying of faith in God to protect you.’ This same idea of trust applies to vision. ‘If God made eyes, obviously He can heal vision problems to see normally. We don’t use mechanical devices to make it better—it’s a matter of trusting God for normal vision.'”

-Robert Huber visits members of the First Century Gospel Church, who believe in the power of prayer over medicine, to get a sense of why a couple let two of their children die of illnesses that could have been treated by doctors.

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Photo: Lydur Skulason

The Decades-Long Quest for a Malaria Vaccine

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“Hoffman rolled up his sleeve and pressed the container—mesh side down—to the inside of his forearm. He felt a tickling sensation as the mosquitoes pricked his skin. Five minutes later, he removed the canister; an Army scientist examined the mosquitoes to confirm that each had sucked Hoffman’s blood. Five other volunteers did the same.

“For the next several days, Hoffman and the other volunteers bit their nails and hoped the vaccine would keep them healthy. (Those who come down with the disease are given drugs to kill the parasites.) By day ten, three volunteers were sick, but Hoffman and two others felt fine. Excitement began to swell; no injected malaria vaccine had come close to 50-percent protection—and this was its very first trial. ‘We thought we were going to win the Nobel Prize,’ Hoffman says.”

– In the Washingtonian, Luke Mullins profiles Dr. Stephen Hoffman, who has been trying to develop a malaria vaccine for the last 30 years. He hasn’t given up. Read more about vaccines.

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Photo by: NIAID

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“In the jargon of economics, the demand for therapeutic drugs is ‘price inelastic’: increasing the price doesn’t reduce how much the drugs are used. Prices are set and raised according to what the market will bear, and the parties who actually pay the drug companies will meet whatever price is charged for an effective drug to which there is no alternative. And so in determining the price for a drug, companies ask themselves questions that have next to nothing to do with the drugs’ costs. ‘It is not a science,’ the veteran drug maker and former Genzyme CEO Henri Termeer told me. ‘It is a feel.’”

– An examination of how pharmaceutical companies determine the price of drugs. Read more on medicine in the Longreads Archive.

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Photo: Rennett Stowe

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‘You’re in Trouble. Am I Right?’: My Unsentimental Education

Debra Monroe, 1977 (Photo courtesy of the author)

Debra Monroe | 2012 | 20 minutes (5,101 words)

Debra Monroe is the author of six books, including the memoir “My Unsentimental Education” which will appear in October 2015. Her nonfiction has appeared in The New York Times, The American Scholar, Doubletake, The Morning News and The Southern Review, and she is frequently shortlisted for The Best American Essays. This essay—which is an excerpt from her forthcoming memoir—first appeared on John Griswold‘s Inside Higher Ed blog, and our thanks to Monroe for allowing us to reprint it here. Read more…

Reading List: The Political Mistress

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From Monica to the D.C. Madam, some of my all-time favorite stories on politics, sex and power:

1. ‘The Gary Hart Story: How It Happened,’ by Jim McGee, Tom Fiedler and James Savage (The Miami Herald, May 10, 1987) and ‘The Gary Hart Story: Part Two’

Gary Hart was frontrunner for the 1988 Democratic presidential nomination when rumors of an extramarital affair began to swirl. He responded to the rumors with a strong denial and a dare: “Follow me around. I don’t care. I’m serious. If anybody wants to put a tail on me, go ahead. They’ll be very bored.” Unfortunately for him, the Miami Herald had already been doing just that. Their intrepid reporting not only uncovered an affair between the senator and a 29 year-old model, but also rewrote the rules of political reporting.

Bonus: “Those Aren’t Rumors” (Dick Polman, Smithsonian Magazine 2008) on how the Gary Hart affair changed the political reporting game.

2. ‘No Way to Treat a Lady,’ by Vicky Ward (Vanity Fair, May 2008)

Deborah Jeane Palfrey, the “D.C. Madam,” delivered high-end escorts to Beltway elite, until the whole thing came crashing down with a fiery conviction, suicide and media spectacle.

3. ‘Til Death Do Us Part: A New Look at Hitler’s Mistress Eva Braun,’ by Klaus Wiegrefe (Der Spiegel, February 2010)

An evil dictator and a pretty blonde from Munich, whose official title was “private secretary,” and who was famously jealous of the Führer’s dog.

4. ‘The Scandal That Rocked Britain,’ by Clive Irving (Newsweek, April 2013)

One of the great scandals in British political history, the Profumo Affair—which paired then War Secretary John Profumo with a teenaged former showgirl—had it all: sex, drugs, photographs, spies and a proto-Clintonian denial.

5. ‘The Dark Side of Camelot,’ by Kitty Kelley (People Magazine, February 1988)

Judith Exner wasn’t just JFK’s mistress, she was also his conduit to the mob.

6. ‘Clinton and the Women,’ by Marjorie Williams (Vanity Fair, May 1998)

On Gennifer Flowers, Paula Jones, Monica Lewinsky, and what the lack of protest reveals about feminism today (or, more accurately, in 1998).

7. ‘Monica Takes Manhattan,’ by Vanessa Grigoriadis (New York Magazine, March 2001)

Of course Vanessa Grigoriadis would write the perfect early-aughts New York magazine piece on Monica Lewinsky’s post-scandal second act as a Manhattan twenty-something.

8. ‘Saint Elizabeth and the Ego Monster,’ by John Heilemann & Mark Halperin (New York Magazine, January 9, 2010)

“My friends insist you’re John Edwards,” Rielle Hunter said. “I tell them no way—you’re way too handsome.”

Yes, that Game Change excerpt. When was the last time you re-read it?

Are we missing anything? Share your story picks in the comments.


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Public Enemies: Social Media Is Fueling Gang Wars in Chicago

Longreads Pick

Gangs in Chicago have used social media sites like Facebook and Twitter to spread inflammatory messages about rivals and incite violence:

“We naturally associate criminal activity with secrecy, with conspiracies hatched in alleyways or back rooms. Today, though, foolish as it may be in practice, street gangs have adopted a level of transparency that might impress even the most fervent Silicon Valley futurist. Every day on Facebook and Twitter, on Instagram and YouTube, you can find unabashed teens flashing hand signs, brandishing guns, splaying out drugs and wads of cash. If we live in an era of openness, no segment of the population is more surprisingly open than 21st-century gang members, as they simultaneously document and roil the streets of America’s toughest neighborhoods.”

Author: Ben Austen
Source: Wired
Published: Sep 17, 2013
Length: 17 minutes (4,452 words)

Tomato Can Blues

Longreads Pick

A small-time fighter’s big-time hoax:

“While Rowan was ferrying drugs in Three Rivers in 2010, before he began cage fighting, he claimed to have lost Gomez’s shipment, maybe worth as much as $80,000. As Rowan told it, a group of thieves jumped him, cracked his ribs and stole the drugs.

“Now, Rowan owed money to impatient people. He tried to lie low, but in January, a group of men beat him up behind Shopko, leaving him with two black eyes, broken ribs and blood on his baseball cap, he told friends at the time.

“Rowan was desperate. Then, while he was watching TV at his girlfriend’s house, a show caught his attention. It was on the Investigation Discovery channel, something about a guy who staged his own death so he could start his life anew.”

Author: Mary Pilon
Published: Sep 18, 2013
Length: 19 minutes (4,812 words)