When Anesthesia Goes Wrong

A teenage boy went into surgery for a broken arm and emerged with brain damage. His mother was determined to figure out what had happened. Turns out, he wasn’t the only young person adversely affected by anesthesia. A riveting medical mystery from Sarah Zhang:

Over the years, Yaremy had talked with colleagues in Venezuela about Uli so relentlessly that word sometimes came back to her of similar cases: nearly always kids, nearly always after routine surgery. An introvert by nature, Yaremy had to learn to badger anyone and everyone for a useful crumb of information.

She began running down some of these rumors: The wife of the son of a friend knew a neurologist who knew an anesthesiologist who knew of a boy who had fallen ill after surgery on a broken forearm. He became patient four. Patient five was the boy whose mother she’d met picking up Botox in Caracas. A physical therapist told her about a boy who’d had cleft-lip surgery—patient six. An old friend from medical school, an anesthesiologist, had examined a boy who developed symptoms after surgery for a cochlear implant. The friend had once been skeptical of Yaremy’s theory, but now he helped her gather data. This boy became the seventh and final patient in the study. . . . A haunting pattern appeared in the cases she was able to pull together. All seven patients in the study had received sevoflurane. Most of them could trace their maternal relatives to Carabobo; Yaremy’s own maternal grandmother was from the state. And all seven had the same T-to-C mutation.