With an unrelenting focus on selling, Mr. Gagosian, 65, has become the most powerful art dealer in the world. He represents the estates and careers of 77 of the world’s top artists, including Pablo Picasso, Alberto Giacometti, Cy Twombly, Richard Serra, Jeff Koons, Damien Hirst and Ed Ruscha. Dealers who track how he prices his gallery shows estimate he sells upwards of $1 billion worth of art a year. Sotheby’s, by comparison, auctioned off $870 million worth of contemporary art last year.